Publication: Expression of cannabinoid receptors in human kidney
Authors
Larrinaga, Gorka ; Varona, Adolfo ; Pérez, Itxaro ; Sanz, Begoña ; Ugalde, Aitziber
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of CB1 and CB2 cannabinoid
receptors and their physiological role in the kidney has
been described in animal models but not in humans. Our
aim in this study was to evaluate the presence of these
receptors in human kidney, adult and fetal. For this
purpose, RT-PCR, western-blot and immunohistochemical
assays were performed. RT-PCR confirmed the
presence of CB1 receptor mRNA receptor and the
absence of the CB2 receptor mRNA in adult and fetal
kidney. Western-blot and immunohistochemical assays
revealed the presence of the CB1 cannabinoid receptor
protein, which displayed a similar distribution in fetal
and adult kidneys. Proximal and distal convoluted tubule
cells and intercalated cells in the collecting ducts showed
marked positivity. Conversely, the CB2 cannabinoid
receptor protein was consistently negative in all cases.
Our data suggest a possible implication of the
endocannabinoid system in the physiology and
development of the human kidney.
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