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Expression profile of metastasis-related genes in invasive oral cancers

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dc.contributor.authorChiang, Yung-Yenes
dc.contributor.authorTsai, Ming-Hsuies
dc.contributor.authorLin, Tze-Yi
dc.contributor.authorChiang, I-Ping
dc.date.accessioned2013-01-22T10:03:55Z
dc.date.available2013-01-22T10:03:55Z
dc.date.issued2008
dc.description.abstractWe used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29836
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOral canceres
dc.subjectPrognosises
dc.subject.other616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleExpression profile of metastasis-related genes in invasive oral cancerses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23,nº10 (2008)