Publication:
Expression profile of metastasis-related genes in invasive oral cancers

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Expression profile of metastasis-related genes in invasive oral cancers.pdf(1.33 MB)
Date
2008
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Authors
Chiang, Yung-Yen ; Tsai, Ming-Hsui ; Lin, Tze-Yi ; Chiang, I-Ping
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.
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Oral cancer , Prognosis
Citation
URI
http://hdl.handle.net/10201/29836
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Histology and histopathology Vol.23,nº10 (2008)
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