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Pituitary tumor transforming gene: An important gene in normal cellular functions and tumorigenesis

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dc.contributor.authorBradshaw, C.es
dc.contributor.authorKakar, S.S.es
dc.date.accessioned2012-05-21T12:08:45Z
dc.date.available2012-05-21T12:08:45Z
dc.date.issued2007
dc.description.abstractPituitary tumor transforming gene (PTTG) is an oncogene which is found to be highly expressed in proliferating cells and in most of the tumors analyzed to date. Overexpression of PTTG induces cellular transformation and promotes tumor development in nude mice. PTTG is regulated by various growth factors including insulin and IGF-1. PTTG is a multifunctional and multidomain protein. Some of the functions of PTTG include inhibition of separation of sister chromatids, expression and secretion of angiogenic and metastatic factors. In this review we focus on expression of PTTG in normal and tumor tissues, define its biological function, its role in tumorigenesis, and its interaction with other proteins that may play important role in mediating tumorigenic function of PTTG.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27549
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectTumorigenesises
dc.subjectAngiogenesises
dc.subject.other616.2 - Patología del aparato respiratorioes
dc.titlePituitary tumor transforming gene: An important gene in normal cellular functions and tumorigenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 2 (2007)