Publication: Pituitary tumor transforming gene: An important gene in normal cellular functions and tumorigenesis
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Date
2007
Authors
Bradshaw, C. ; Kakar, S.S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pituitary tumor transforming gene (PTTG) is
an oncogene which is found to be highly expressed in
proliferating cells and in most of the tumors analyzed to
date. Overexpression of PTTG induces cellular
transformation and promotes tumor development in nude
mice. PTTG is regulated by various growth factors
including insulin and IGF-1. PTTG is a multifunctional
and multidomain protein. Some of the functions of
PTTG include inhibition of separation of sister
chromatids, expression and secretion of angiogenic and
metastatic factors. In this review we focus on expression
of PTTG in normal and tumor tissues, define its
biological function, its role in tumorigenesis, and its
interaction with other proteins that may play important
role in mediating tumorigenic function of PTTG.
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Citation
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