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Crescentic glomerulonephritis - a manifestation of a nephritogenic Thl response?

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dc.contributor.authorKitching, A.R.
dc.contributor.authorHoldsworth, S. R.
dc.contributor.authorTipping, P. G.
dc.date.accessioned2020-07-23T14:41:13Z
dc.date.available2020-07-23T14:41:13Z
dc.date.issued2000
dc.description.abstractCrescentic glomerulonephritis (GN) is the histopathological correlate of the clinical syndrome of rapidly progressive glomerulonephritis. Glomerular crescent formation complicates proliferative forms of GN and indicates severe disease with a poor renal prognosis. In the past 10 years evidence from experimental models of GN and from human disease has accumulated suggesting that crescentic glomerulonephritis is a manifestation of a delayed type hypersensitivity (DTH)-like response to nephritogenic antigens. The elucidation of T helper 1 (Thl) and Th2 subsets in mice and in humans has led to the hypothesis that crescentic GN is a manifestation of a Thl predominant DTH mediated immune response. Recent experiments performed mainly in a murine model of crescentic glomerulonephritis have tested this hypothesis. Crescent formation in this model is substantially interleukin (IL)-12 and interferon-y (IFN-y) dependent. Administration of IL-12, deletion of endogenous IL-4 or IL-lO results in enhanced disease , while administration of exogenous IL-4 and/or IL-IO reduces crescentic injury. These findings, together with the available evidence from human studies (examining the pattern of immune effectors in glomeruli, data on cytokine production by peripheral blood mononuclear cells and case reports of the induction of proliferative and/or crescentic GN by administration of IFN-y or IL2) suggest that human crescentic GN is manifestation of a Thl mediated DTH-like nephritogenic immune response.es
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dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol. 15, n.º 3 (2000)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/95187
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectThl cellses
dc.subjectGlomerulonephritises
dc.subjectDelayed type hypersensitivityes
dc.subjectMacrophageses
dc.subjectCytokineses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleCrescentic glomerulonephritis - a manifestation of a nephritogenic Thl response?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 3 (2000)