Publication: Crescentic glomerulonephritis -
a manifestation of a nephritogenic Thl response?
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Date
2000
Authors
Kitching, A.R. ; Holdsworth, S. R. ; Tipping, P. G.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Crescentic glomerulonephritis (GN) is the
histopathological correlate of the clinical syndrome of
rapidly progressive glomerulonephritis. Glomerular
crescent formation complicates proliferative forms of
GN and indicates severe disease with a poor renal
prognosis. In the past 10 years evidence from
experimental models of GN and from human disease has
accumulated suggesting that crescentic glomerulonephritis is a manifestation of a delayed type
hypersensitivity (DTH)-like response to nephritogenic
antigens. The elucidation of T helper 1 (Thl) and Th2
subsets in mice and in humans has led to the hypothesis
that crescentic GN is a manifestation of a Thl
predominant DTH mediated immune response. Recent
experiments performed mainly in a murine model of
crescentic glomerulonephritis have tested this
hypothesis. Crescent formation in this model is
substantially interleukin (IL)-12 and interferon-y (IFN-y)
dependent. Administration of IL-12, deletion of
endogenous IL-4 or IL-lO results in enhanced disease ,
while administration of exogenous IL-4 and/or IL-IO
reduces crescentic injury. These findings, together with
the available evidence from human studies (examining
the pattern of immune effectors in glomeruli, data on
cytokine production by peripheral blood mononuclear
cells and case reports of the induction of proliferative
and/or crescentic GN by administration of IFN-y or IL2) suggest that human crescentic GN is manifestation of
a Thl mediated DTH-like nephritogenic immune
response.
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Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
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