Publication: Effect of antibiotics and NSAIDs on ciclooxygenase-2 in the enamel mineralization
Authors
Serna Muñoz, Clara ; Pérez Silva, Amparo ; Solano, Francisco ; Vicente, Ascensión ; Ortiz Ruiz, Antonio José ; Castells Mora, María Teresa
item.page.secondaryauthor
item.page.director
Publisher
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1038/s41598-018-22607-z
item.page.type
info:eu-repo/semantics/article
Description
©2018. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the Published, version of a Published Work that appeared in final form in Scientific Reports. To access the final edited and published work see https://doi.org/10.1038/s41598-018-22607-z
Abstract
The objective of this study was to determine whether the use of the most commonly prescribed antibiotics
and non-steroidal anti-inflammatory drugs in childhood could disturb enamel mineralization. Forty-two
Swiss mice were divided into seven groups: controls; amoxicillin; amoxicillin/clavulanate; erythromycin;
acetaminophen; ibuprofen and celecoxib, to inhibit cyclooxygenase 2 (COX2). SEM-EDX analysis
was conducted on all cusps of the third molars. Calcium (Ca), phosphorus (P), aluminum, potassium,
sodium, magnesium and chlorine were quantified. The stoichiometric Ca/P molar ratios were calculated.
Immunohistochemical quantification of COX2 in incisors was carried out by image analysis using COX2-
specific immunostaining. Groups treated with antibiotics showed no significant differences in the content
of the chemical elements. Only acetaminophen and celecoxib showed a significant decrease in Ca and P
compared with the control samples. Ca/P ratios showed no difference. Groups treated with amoxicillin,
amoxicillin/clavulanate, erythromycin and acetaminophen showed significantly lower amounts of
immunoreactive COX2 at the enamel organ maturation stage of the mouse incisors. Our results suggest
that COX2 is involved in the maturation stage of the enamel organ and that its inhibition would appear to
alter amelogenesis, producing hypomineralization.
publication.page.subject
Citation
Scientific Reports 2018 8: 4132
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/