Publication: Emerging significance of ER-coregulator PELP1-MNAR in cancer
Authors
Nair, S. ; Vadlamudi, R.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The estrogen receptors ERa and ERß have
been implicated in the progression of a wide variety of
cancers. The actions of ER are regulated by ER
coregulator proteins, including proline-, glutamic acidand
leucine-rich-protein-1 (PELP1/MNAR). PELP1 has
been shown to participate in both genomic and
nongenomic functions of ER. The expression and
localization of PELP1/MNAR are deregulated in a wide
variety of tumors and have been implicated in the
development of hormonal resistance in cancer cell lines.
Emerging data suggest that PELP1/MNAR interacts with
many proteins and activates several oncogenes,
including Src kinase, phosphotidyl inositol 3 kinase
(PI3K), and signal transducers and activators of
transcription 3 (STAT3). These new results suggest that
PELP1/MNAR may act as an oncogene as well as
cooperating with other oncogenes. Thus, PELP1/MNAR
may contribute to the tumorigenic potential of cancer
cells by serving as a scaffolding protein that couples
various signaling complexes with ER.
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