Publication: Sex- and strain-dependent histological features of the
proximal convoluted tubular epithelium of mouse kidney:
association with lysosomes containing apolipoprotein B
| dc.contributor.author | Yabuki, A. | es |
| dc.contributor.author | Suzuki, S. | es |
| dc.contributor.author | Matsumoto, M. | |
| dc.contributor.author | Nishinakagawa, H. | |
| dc.date.accessioned | 2011-05-11T10:57:34Z | |
| dc.date.available | 2011-05-11T10:57:34Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | In the present study, we performed comparative histological observations of ICR, BALB/c, C57BL/6, C3H/HeN and DBA/2 mice kidneys. Sex and strain differences were observed in the appearance of vacuolar structures of the proximal convoluted tubules (toluidine blue-positive granules in osmium-postfixed epoxy-resin sections). These features were especially remarkable in male DBA/2 mice. The vacuolar structures in male DBA/2 mice showed heterogeneous staining with Sudan B in frozen sections and appeared under an electron microscope as multilammelar giant dense bodies. In addition, these dense bodies showed heterogeneous acid phosphatase reactions. Immunohistochemical analyses of these structures for apolipoprotein B showed strong positive reactions. These results suggested that vacuolar structures in the proximal convoluted tubules, which were remarkable in male DBA/2 mice, were giant lysosomes containing apolipoprotein B. | es |
| dc.format | application/pdf | es |
| dc.format.extent | 7 | es |
| dc.identifier.issn | 0213-3911 | es |
| dc.identifier.uri | http://hdl.handle.net/10201/20748 | |
| dc.language | eng | es |
| dc.publisher | Murcia : F. Hernández | es |
| dc.relation.ispartof | Histology and histopathology | es |
| dc.rights | info:eu-repo/semantics/openAccess | es |
| dc.subject | Kidney | es |
| dc.subject | Lysosome | es |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
| dc.title | Sex- and strain-dependent histological features of the proximal convoluted tubular epithelium of mouse kidney: association with lysosomes containing apolipoprotein B | es |
| dc.type | info:eu-repo/semantics/article | es |
| dspace.entity.type | Publication | es |
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