Publication: Sex- and strain-dependent histological features of the
proximal convoluted tubular epithelium of mouse kidney:
association with lysosomes containing apolipoprotein B
Authors
Yabuki, A. ; Suzuki, S. ; Matsumoto, M. ; Nishinakagawa, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the present study, we performed
comparative histological observations of ICR, BALB/c,
C57BL/6, C3H/HeN and DBA/2 mice kidneys. Sex and
strain differences were observed in the appearance of
vacuolar structures of the proximal convoluted tubules
(toluidine blue-positive granules in osmium-postfixed
epoxy-resin sections). These features were especially
remarkable in male DBA/2 mice. The vacuolar
structures in male DBA/2 mice showed heterogeneous
staining with Sudan B in frozen sections and appeared
under an electron microscope as multilammelar giant
dense bodies. In addition, these dense bodies showed
heterogeneous acid phosphatase reactions.
Immunohistochemical analyses of these structures for
apolipoprotein B showed strong positive reactions.
These results suggested that vacuolar structures in the
proximal convoluted tubules, which were remarkable in
male DBA/2 mice, were giant lysosomes containing
apolipoprotein B.
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