Publication: A brief review of chordomas: pathogenesis, prognostic factors and therapeutic targets
Authors
Hai, Bao ; Ma, Yunlong ; Liu, Xiaoguang
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-080
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info:eu-repo/semantics/article
Description
Abstract
Chordomas are rare but locally aggressive
cancer, which originate from primitive notochord
remnants. Guidelines have recently been proposed to
include the option of choosing chordomas in different
locations. However, there is still a great challenge in the
modern management of chordomas, primarily due to the
high recurrence rate and poor prognosis. On this basis,
there is a high demand for new therapeutic approaches
and reliable prognostic factors. Recent progress in
studying the molecular basis of this specific type of
cancer has deepened the understanding of this
mechanism, which overall facilitates the discovery of
specific biomarkers or indicators of the disease. It also
gives rise to potential targeted therapies against
chordomas as evidenced by the fact that some RTK
inhibitors in a clinical context have been evaluated in
relation to chordomas. This article summarizes these
achievements including the studies relative to
pathogenesis, prognostic factors, and targeted therapies
for chordomas. The theme of existing problems is also
mentioned, which would facilitate general future efforts
in this field.
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Citation
Histology and Histopathology, Vol.34, nÂş5, (2019)
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Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/