Publication: Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization
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Date
2007
Authors
Kondoh, H. ; Lleonart, M.E. ; Bernard, D. ; Gil, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Reactive oxygen species (ROS) play a
crucial role not only in the physiological signal
transduction but also in the pathogenesis of several
human diseases such as atherosclerosis, neurodegenerative
diseases, metabolic disorders, aging or
cancer amongst others. Oxidative stress is also
responsible for cellular and organism senescence, in
accordance with what Harman initially proposed in the
free radical theory of aging. Recent findings support the
notion that protection from oxidative stress can increase
life span significantly. We reported that enhanced
glycolysis could modulate cellular life span with
reduction of oxidative stress. Moreover, the tumor
suppressor gene p53 controls post-transcriptionally the
level of the glycolytic enzyme, phosphoglycerate mutase
(PGM). As enhanced glycolysis is a distinctive and
prominent feature of cancer cells (termed the Warburg
effect), our findings disclosed a novel aspect of the
Warburg effect: the connection between senescence and
oxidative stress.
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