Publication: lmmunohistochemical localization of collagens and fibronectin in human breast neoplasms
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Date
1987
Authors
Al-Adnani, M. S. ; Taylor, S. ; Al-Bader, A.A. ; Al-Zuhair, A.G.H. ; McGee, James O`D.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Forty four specimens from neoplastic,
hyperplastic and normal human breast tissues were
studied for localization of collagens and fibronectin.
Affinity purified antihuman type I, I11 and IV collagens
and antifibronectins were utilized by the indirect
immunoperoxidase technique on fixed and paraffinembedded
sections. 86% of the cell cytoplasm of
infiltrating ductal and 83% of the lobular cancers were
positively stained for collagen type I and 111. Collagen
type IV, however, was detected in 100% of infiltrating
ductal and 83% of lobular carcinomas. Focal cytoplasmic
staining is a predominant feature for all antigens in the
intraduct carcinoma while a diffuse pattern is
encountered in the infiltrating types. Intact basement
membranes in various lesions always stained for type IV
collagen and showed variable staining for type I11
collagen and fibronectin. Epithelia of normal, benign,
hyperplastic breast and most medullary carcinoma were
negative for the three collagen types.
Our results are in favour of the view that infiltrating
breast carcinoma cells produce inappropriately the
majority of collagens and inconsistently other proteins
such as fibronectin.
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