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Risk factors of DAIR failure and validation of the KLIC score

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Date
2022-03-24
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Hernández Torres, Alicia ; Bernaus M, Rubio Á, Soriano A, et al ; Bernaus, Martí ; Auñón-Rubio, Álvaro ; Monfort-Mira, Montserrat ; Arteagoitia-Colino, Iaria ; Martínez-Ros, Javier ; Castellanos, Juan ; Lamo Espinosa, José María ; Argüelles, Francisco ; Veloso, Margarita ; Gómez García, Lucía ; Anglès Crespo, Francesc ; Sánchez Fernández, Joel ; Murias Álvarez, Juan ; Martí Garín, David ; Hernández-González, Nerea ; Villarejo Fernández, Borja ; Valero Cifuentes, Gregorio ; Molina-González, José ; Coifman-Lucena, Ismael ; Esteban-Moreno, Jaime ; Demaria, Pablo ; Esteve-Palau, Erika ; Pozo, José Luis del ; Suárez, Álvaro ; Carmona Torre, Francisco ; Darás, Álvaro ; Baeza, José ; Font Vizcarra, Lluís
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Publisher
SAGE Publications
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Medicina
DOI
https://doi.org/10.1089/sur.2021.320
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info:eu-repo/semantics/article
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Abstract
Background: Debridement, antibiotic agents, and implant retention (DAIR) is a currently accepted approach for the treatment of early prosthetic joint infections (PJI). The success of a DAIR procedure has shown variable results throughout the published literature. Scoring systems such as the Kidney, Liver, Index surgery, Cemented prosthesis, and C-reactive protein value (KLIC) score for the selection of patients that are likely to benefit from DAIR have proved to be helpful in decision making. Our study aims to further validate the KLIC score using a large external multicentric cohort and to evaluate other risk factors for failure. Patients and Methods: A retrospective analysis of patients with an early acute PJI who were treated with DAIR and recorded in a database of eight Spanish university hospitals was performed. According to pre-operative variables of the KLIC study, patients were categorized into five groups: group A, ≤2 points; group B, 2.5–3.5 points; group C, 4–5 points; group D, 5.5–6.5 points; and group E, ≥7 points. Failure rates were compared between groups at 60 days and after 60 days of DAIR. Further variables for risk of failure were also analyzed. Results: A total of 455 patients with early acute PJI were included in the analyses. At 60 days, patients presenting with pre-operative elevated C-reactive protein serum levels, Staphylococcus aureus, and polymicrobial infections were associated with failure. Failure rates recorded were 12% for group A (n = 210), 18% for group B (n = 83), 26% for group C (n = 89), 24% for group D (n = 66), and 0% for group E (n = 7). Univariable analysis between consecutive groups of the KLIC score showed no differences for failure before 60 days of the DAIR procedure. Scheduled surgery and having the procedure performed by a specialized unit were also identified as important factors for DAIR success. Conclusions: Our results suggest the KLIC score was not useful for predicting failure in our cohort. Furthermore, our results indicate a specialized unit should conduct DAIR procedures.
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Antibiotics , Debridement , KLIC score , Prosthetic joint infection , Validation
Citation
Surgical Infections. 2022;23(3):280-287
URI
http://hdl.handle.net/10201/216561
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