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Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration

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dc.contributor.authorGarcía Pérez, Daniel
dc.contributor.authorNúñez Parra, Cristina
dc.contributor.authorLaorden Carrasco, María Luisa
dc.contributor.authorMilanés Maquilón, María Victoria
dc.contributor.departmentFarmacología
dc.contributor.otherFarmacia
dc.date.accessioned2026-02-24T08:02:37Z
dc.date.available2026-02-24T08:02:37Z
dc.date.copyright© 2014, Elsevier B.V. All rights reserved
dc.date.issued2014-07-30
dc.description.abstractOpiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We observed that single morphine injection and chronic morphine increased glial fibrillary acidic protein expression in the ventral tegmental area (VTA). Interestingly, single morphine injection and chronic morphine increased VTA midkine and pleiotrophin mRNA expression. Given these results, we hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.
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dc.identifier.citationGarcía-Pérez D, Luisa Laorden M, Núñez C, Victoria Milanés M. Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration. J Neuroimmunol. 2014 Sep 15;274(1-2):244-8. doi: 10.1016/j.jneuroim.2014.07.017
dc.identifier.doihttps://doi.org/10.1016/j.jneuroim.2014.07.017
dc.identifier.eissn1872-8421
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/10201/211401
dc.languageeng
dc.publisherElsevier
dc.relationThis work was supported by grants from Ministerio de Ciencia e Innovación (SAF/FEDER 2009-07178; SAF/FEDER 2010-17907), Spain; Red de Trastornos Adictivos (RETICS, RD12/0028/0003), Spain; Fundación Séneca (15405/PI/10), Región de Murcia, Spain. Daniel García-Pérez was supported by a fellowship from Ministerio de Ciencia e Innovación (AP2009-2379).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S016557281400232X?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectReward pathway
dc.subjectGlial fibrillary acidic protein
dc.subjectMidkine
dc.subjectPleiotrophin
dc.subjectOpiate dependence
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleGlial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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