Publication: Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration
Authors
García Pérez, Daniel ; Núñez Parra, Cristina ; Laorden Carrasco, María Luisa ; Milanés Maquilón, María Victoria
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Farmacia
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.jneuroim.2014.07.017
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info:eu-repo/semantics/article
Description
Abstract
Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We observed that single morphine injection and chronic morphine increased glial fibrillary acidic protein expression in the ventral tegmental area (VTA). Interestingly, single morphine injection and chronic morphine increased VTA midkine and pleiotrophin mRNA expression. Given these results, we hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.
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Citation
García-Pérez D, Luisa Laorden M, Núñez C, Victoria Milanés M. Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration. J Neuroimmunol. 2014 Sep 15;274(1-2):244-8. doi: 10.1016/j.jneuroim.2014.07.017
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