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Beyond an oncogene, Lin28 is a master regulator of cancer progression

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dc.contributor.authorWang, Xuefei
dc.contributor.authorWeng, Mingjiao
dc.contributor.authorJin, Yinji
dc.contributor.authorYang, Weiwei
dc.contributor.authorWang, Xin
dc.contributor.authorWu, Di
dc.contributor.authorWang, Tianzhen
dc.contributor.authorLi, Xiaobo
dc.date.accessioned2022-04-06T07:25:35Z
dc.date.available2022-04-06T07:25:35Z
dc.date.issued2018
dc.description.abstractThe RNA binding protein Lin28 is increased in most human malignancies, and elevated Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 functions as a master oncogene and is involved in almost all hallmarks of cancer. In this review, we summarize the aberrant molecular expression mechanisms and pathological roles of Lin28 in cancer progression. Moreover, we elaborate on the established molecular mechanisms, from the transcriptional level to the post-transcriptional and translational levels, by which Lin28 regulates cancer progression.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş4, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-922
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118783
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLin28es
dc.subjectRNA binding proteines
dc.subjectOncogenees
dc.subjectCancer progressiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleBeyond an oncogene, Lin28 is a master regulator of cancer progressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş4 (2018)