Publication: Toxicity of 2,2',4,4',5,5'-hexachlorobiphenyl in the rat liver. An electron microscope study
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Date
1994
Authors
MacLellan, K. ; Singh, A. ; Chu, I. ; Villeneuve, David C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Morphological effects on the liver of
Sprague-Dawley rats administered orally 2,2',4,4',5,5'-
hexachlorobiphenyl (PCB), congener #153, were
analyzed. Treatment diets were prepared by dissolving
the congener in 4% corn oil. Ten animals of either sex in
each group were placed on the respective diets that
contained 50, 500. 5.000, or 50,000 ppb congener. Ten
animals of each sex served as the control that had only
the oil added to the diets. Thirteen weeks after the onset
of dosing, the animals were euthanized and liver samples
were obtained from the animals and prepared for
electron microscopy.
Animals exposed to the congener showed (in a doserelated
manner) a marked increase in smooth endoplasmic
reticulum profiles, and in the number of lipid
droplets in many parenchyma1 cells. Mitochondrial
abnormalities such as dumbbell shapes, and in others,
the cristae that were oriented parallel to the long axis of
the organelle were present. The magnitude of
morphologic alterations did not reveal gender
differences. The results indicate mild hepatotoxicity of
the congener in the rat.
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