Publication: The effects of cyclophosphamide on pulmonary thrombopoiesis in rats
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Date
1998
Authors
Sulkowski, S. ; Sulkowska, M. ; Musiatowicz, B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cyclophosphamide (CP), an antineoplastic
and immunosuppresive agent, even when administered
in large doses, slightly affects the quantity of blood
platelets. The aim of the present study was to analyse the
effect of single intraperitoneal administration of CP
(150mg/kg b.w.) on the quantitative changes in platelets
obtained from the left and right ventricle of the heart, as
well as to evaluate the occurrence of megakaryocytes in
lung tissue depending on the period of time that passed
from CP administration.
In control subgroups, fewer platelets were found in
the blood collected from the RV compared with the left
ventricle at all time intervals. After 1 and 3 days
following i.p, administration of CP, a decrease was
observed in the number of platelets both in the blood
from the right ventricle and left ventricle when
compared with control. However, after 14 days, the
number of platelets in the blood from the left ventricle
was higher, compared with the left ventricle and right
ventricle of control animals, and significantly higher
(p<0.001747), compared with their number obtained
from the right ventricle of CP-receiving animals.
Simultaneous ultrastructural examinations with
transmission electron microscopy revealed the increased
number of platelets in the lung vascular bed of CPreceiving
rats at all time intervals. However, megakaryocytes
were found 7 and 14 days after administration of
CP. The findings clearly indicate that the lungs could be
a major place of thrombopoiesis following therapy with
a single large dose of CP.
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