Publication:
Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases

Simple item page
dc.contributor.authorRivard, A.es
dc.contributor.authorAndres, V.es
dc.date.accessioned2011-02-22T11:21:32Z
dc.date.available2011-02-22T11:21:32Z
dc.date.issued2000
dc.description.abstractAtherosclerosis is the principal cause of myocardial infarction, stroke, and peripheral vascular disease, accounting for nearly half of all mortality in developed countries. For example, it has been estimated that atherosclerosis leads to approximately 500,000 deaths from coronary artery disease and 150,000 deaths from stroke every year in the United States (American Heart Association, 1996). Percutaneous transluminal angioplasty has become a well-established technique for revascularization of occluded arteries. However, the long-term efficacy of the procedure remains limited by progressive vessel renarrowing (restenosis) within the following few months after angioplasty. Abnormal vascular smooth muscle cell (VSMC) proliferation is thought to play an important role in the pathogenesis of both atherosclerosis and restenosis. Accordingly, considerable effort has been devoted to elucidate the mechanisms that regulate cell cycle progression in VSMCs. In the present article, we will review the different factors that are involved in the control of VSMC proliferation, especially in the context of cardiovascular disease. Ultimately, a thorough understanding of these regulatory networks may lead to the development of novel drug and gene therapies for the treatment of cardiovascular diseases. Therapeutic approaches that targeted specific cell-cycle control genes or growth regulatory molecules which effectively inhibited neointimal lesion formation will be also discussed.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19322
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCell cyclees
dc.subjectAtherosclerosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleVascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases.pdf
Size:
10.59 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.15, nº 2 (2000)