Publication: Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
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Date
2000
Authors
Rivard, A. ; Andres, V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Atherosclerosis is the principal cause of
myocardial infarction, stroke, and peripheral vascular
disease, accounting for nearly half of all mortality in
developed countries. For example, it has been estimated
that atherosclerosis leads to approximately 500,000
deaths from coronary artery disease and 150,000 deaths
from stroke every year in the United States (American
Heart Association, 1996). Percutaneous transluminal
angioplasty has become a well-established technique for
revascularization of occluded arteries. However, the
long-term efficacy of the procedure remains limited by
progressive vessel renarrowing (restenosis) within the
following few months after angioplasty. Abnormal
vascular smooth muscle cell (VSMC) proliferation is
thought to play an important role in the pathogenesis of
both atherosclerosis and restenosis. Accordingly,
considerable effort has been devoted to elucidate the
mechanisms that regulate cell cycle progression in
VSMCs. In the present article, we will review the
different factors that are involved in the control of
VSMC proliferation, especially in the context of
cardiovascular disease. Ultimately, a thorough
understanding of these regulatory networks may lead to
the development of novel drug and gene therapies for the
treatment of cardiovascular diseases. Therapeutic
approaches that targeted specific cell-cycle control genes
or growth regulatory molecules which effectively
inhibited neointimal lesion formation will be also
discussed.
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