Publication:
The suppressive effects of miR-1180-5p on the proliferation and tumorigenicity of bladder cancer cells

Simple item page
dc.contributor.authorGe, Qiangqiang
dc.contributor.authorWang, Chenghe
dc.contributor.authorChen, Zhong
dc.contributor.authorLi, Fan
dc.contributor.authorHu, Jia
dc.contributor.authorYe, Zhangqun
dc.date.accessioned2022-02-03T09:21:04Z
dc.date.available2022-02-03T09:21:04Z
dc.date.issued2017
dc.description.abstractIn our previous research, we have reported that a candidate microRNA (miR-1180-5p) has the capacity to induce overexpression of tumor suppressor gene p21 and inhibit the growth of human bladder cancer (BCa) cell lines in vitro. However, the exact mechanism as to how miR-1180-5p suppresses BCa cell proliferation remains unknown, and the inhibitory effect of miR-1180-5p in vivo also need to be investigated. In the present study, we found that the expression level of miR-1180-5p was lower in BCa cells than in normal human urothelial cells. Furthermore, we found that overexpression of p21, activated by miR-1180-5p, interfered with cell cycle progress by inhibiting the cell cycle related proteins (CDK4, CDK6, Cyclin D1 and Cyclin A2), and thereby suppressed BCa cell proliferation. In addition, miR-1180-5p also suppressed the tumor growth in vivo significantly. Taken together, our study provides evidence that up-regulation of p21 is mainly responsible for the suppressive effect of miR1180-5p on BCa cells and miR-1180-5p can significantly inhibit tumorigenicity in vivo.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.32, nÂş1, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-772
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/116704
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmiR-1180-5pes
dc.subjectProliferationes
dc.subjectBladder canceres
dc.subjectTumorigenicityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleThe suppressive effects of miR-1180-5p on the proliferation and tumorigenicity of bladder cancer cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ge-32-77-86-2017.pdf
Size:
10.63 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.32, nÂş1 (2017)