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STAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung cancer

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dc.contributor.authorLi, Jili
dc.contributor.authorZhu, Yingying
dc.contributor.authorPeng, Jianyue
dc.contributor.authorYang, Lan
dc.contributor.authorZhang, Li
dc.contributor.authorLi, Lei
dc.date.accessioned2025-05-08T07:51:05Z
dc.date.available2025-05-08T07:51:05Z
dc.date.issued2025
dc.description.abstractSignal transducer and activator of transcription factor 3 (STAT3)/phosphorylated STAT3 (p-STAT) play a critical role in tumorigenesis, however, there is limited information on its prognostic value in non-small cell lung cancer (NSCLC). To address this question, 239 lung cancer and 71 normal lung tissue samples were obtained in this study. Immunohisto-chemistry was applied to detect STAT3/p-STAT3 expression. Pearson’s Chi-squared test and the Kaplan-Meier method were conducted to evaluate associations with patients’ clinical characteristics and survival. According to our results, STAT3/p-STAT3 was significantly upregulated in lung cancer tissue (p<0.001). Moreover, p-STAT3 expression was significantly correlated with age (p=0.046) and pathological types (p=0.037). In survival analysis, STAT3 positivity was negatively associated with survival in patients older than 60 years (p=0.043) but failed to be an independent prognostic factor in multivariate analysis (p=0.083). Therefore, STAT3/p-STAT3 may serve as a critical biomarker in NSCLCes
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 40, nÂş06 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-827
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/154200
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNSCLCes
dc.subjectPrognosises
dc.subjectSTAT3es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleSTAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nÂş6 (2025)