Publication: STAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung cancer
Authors
Li, Jili ; Zhu, Yingying ; Peng, Jianyue ; Yang, Lan ; Zhang, Li ; Li, Lei
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-827
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info:eu-repo/semantics/article
Description
Abstract
Signal transducer and activator of transcription factor 3 (STAT3)/phosphorylated STAT3 (p-STAT) play a critical role in tumorigenesis, however, there is limited information on its prognostic value in non-small cell lung cancer (NSCLC). To address this question, 239 lung cancer and 71 normal lung tissue samples were obtained in this study. Immunohisto-chemistry was applied to detect STAT3/p-STAT3 expression. Pearson’s Chi-squared test and the Kaplan-Meier method were conducted to evaluate associations with patients’ clinical characteristics and survival. According to our results, STAT3/p-STAT3 was significantly upregulated in lung cancer tissue (p<0.001). Moreover, p-STAT3 expression was significantly correlated with age (p=0.046) and pathological types (p=0.037). In survival analysis, STAT3 positivity was negatively associated with survival in patients older than 60 years (p=0.043) but failed to be an independent prognostic factor in multivariate analysis (p=0.083). Therefore, STAT3/p-STAT3 may serve as a critical biomarker in NSCLC
Citation
Histology and Histopathology Vol. 40, nÂş06 (2025)
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