Effect of SonoVue on the synovial membrane in rabbit knees

Domenech, Ernesto; Bern Serna, Juan de Dios; Polo, Luis; Reus Pintado, Manuel; Berná Mestre, Juan de Dios; Canteras, Manuel

Publication:
Effect of SonoVue on the synovial membrane in rabbit knees

dc.contributor.author	Domenech, Ernesto
dc.contributor.author	Bern Serna, Juan de Dios
dc.contributor.author	Polo, Luis
dc.contributor.author	Reus Pintado, Manuel
dc.contributor.author	Berná Mestre, Juan de Dios
dc.contributor.author	Canteras, Manuel
dc.contributor.department	Dermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned	2025-01-17T11:32:52Z
dc.date.available	2025-01-17T11:32:52Z
dc.date.issued	2011-09-01
dc.description	©2011 by the American Institute of Ultrasound in Medicine. This document is the Published Manuscript version of a Published Work that appeared in final form in Journal of Ultrasound in Medicine. To access the final edited and published work see https://doi.org/10.7863/jum.2011.30.9.1241
dc.description.abstract	Objectives: The purpose of this study was to evaluate the effect of intra-articular injection of SonoVue (sulfur hexafluoride with a phospholipid shell; Bracco SpA, Milan, Italy) on the synovial membrane in an animal model. Methods: Twenty-one New Zealand White rabbits (42 knees) were used in this study. We injected the knees with normal saline (saline group; n = 21) and SonoVue (SonoVue group; n = 21). A histologic examination of the knees was performed out at 3 and 12 hours and 3, 7, 15, 30, and 45 days after injection. Four histologic parameters (synovial hyperplasia, synovial stroma, vascular dilatation, and inflammatory infiltrates) were graded separately. Results: We found no significant differences in this study for synovial hyperplasia, vascular dilatation, or inflammatory infiltrates between the saline and SonoVue groups. A significant difference was only observed for synovial stroma (P < .05), and most of the histologic changes were mild in the saline group and moderate in the SonoVue group. The histologic changes observed in this study are considered transitory and reversible. Conclusions: The results suggest that intra-articular injection of SonoVue is a safe procedure.	es
dc.format	application/pdf	es
dc.format.extent	6	es
dc.identifier.citation	Journal of Ultrasound in Medicine´, 2011, Vol. 30, Issue 9, pp. 1241-1246
dc.identifier.doi	https://doi.org/10.7863/jum.2011.30.9.1241
dc.identifier.issn	Print: 0278-4297
dc.identifier.issn	Electronic: 1550-9613
dc.identifier.uri	http://hdl.handle.net/10201/148676
dc.language	eng	es
dc.publisher	Wiley	es
dc.relation	Sin financiación externa a la Universidad	es
dc.relation.publisherversion	https://onlinelibrary.wiley.com/doi/10.7863/jum.2011.30.9.1241
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Knee joint	es
dc.subject	Ultrasound	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología	es
dc.title	Effect of SonoVue on the synovial membrane in rabbit knees	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es