Publication:
Effect of SonoVue on the synovial membrane in rabbit knees

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S1-2011, Sonovue rodillas conejos.pdf(366.63 KB)
Date
2011-09-01
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Authors
Domenech, Ernesto ; Bern Serna, Juan de Dios ; Polo, Luis ; Reus Pintado, Manuel ; Berná Mestre, Juan de Dios ; Canteras, Manuel
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Publisher
Wiley
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Dermatología, Estomatología, Radiología y Medicina Física
DOI
https://doi.org/10.7863/jum.2011.30.9.1241
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info:eu-repo/semantics/article
Description
©2011 by the American Institute of Ultrasound in Medicine. This document is the Published Manuscript version of a Published Work that appeared in final form in Journal of Ultrasound in Medicine. To access the final edited and published work see https://doi.org/10.7863/jum.2011.30.9.1241
Abstract
Objectives: The purpose of this study was to evaluate the effect of intra-articular injection of SonoVue (sulfur hexafluoride with a phospholipid shell; Bracco SpA, Milan, Italy) on the synovial membrane in an animal model. Methods: Twenty-one New Zealand White rabbits (42 knees) were used in this study. We injected the knees with normal saline (saline group; n = 21) and SonoVue (SonoVue group; n = 21). A histologic examination of the knees was performed out at 3 and 12 hours and 3, 7, 15, 30, and 45 days after injection. Four histologic parameters (synovial hyperplasia, synovial stroma, vascular dilatation, and inflammatory infiltrates) were graded separately. Results: We found no significant differences in this study for synovial hyperplasia, vascular dilatation, or inflammatory infiltrates between the saline and SonoVue groups. A significant difference was only observed for synovial stroma (P < .05), and most of the histologic changes were mild in the saline group and moderate in the SonoVue group. The histologic changes observed in this study are considered transitory and reversible. Conclusions: The results suggest that intra-articular injection of SonoVue is a safe procedure.
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Knee joint , Ultrasound
Citation
Journal of Ultrasound in Medicine´, 2011, Vol. 30, Issue 9, pp. 1241-1246
URI
http://hdl.handle.net/10201/148676
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