Publication: The dexamethasone induced osteogenic differentiation of dental follicle cells
Authors
Morsczeck, Christian ; Reichert, Torsten E.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-907
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info:eu-repo/semantics/article
Description
Abstract
Mesenchymal stem cells are excellent for in
vitro studies about biological processes during the
differentiation of osteogenic progenitor cells into
mineralizing cells such as osteoblasts. Human dental
follicle cells (DFCs) are dental mesenchymal stem cells
and they can be isolated from third molar teeth. Because
DFCs are the genuine progenitor cells of periodontal
tissue cells, they have been used for the evaluation of
molecular mechanisms during the differentiation of
undifferentiated stem cells into alveolar osteoblasts and
cementoblasts. To reveal molecular mechanisms of
osteogenic differentiation, initial studies investigated the
proteome and the transcriptome of DFCs after the
induction of the osteogenic differentiation with the
glucocorticoid dexamethasone. These studies showed for
example that dexamethasone induces the transcription
factor ZBTB16 (zinc finger and BTB domain containing
protein 16) and that ZBTB16 is crucial for osteogenic
differentiation of DFCs. This article is a survey of the
molecular mechanisms in DFCs during osteogenic
differentiation with dexamethasone.
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Citation
Histology and Histopathology, Vol.32, nÂş12, (2017)
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Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/