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Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing

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dc.contributor.authorCastro, Begoña
dc.contributor.authorPalomares, Teodoro
dc.contributor.authorAzcoitia, Iker
dc.contributor.authorBastida, Felix
dc.contributor.authordel Olmo, Maite
dc.contributor.authorSoldevilla, Javier J.
dc.contributor.authorAlonso-Varona, Ana
dc.date.accessioned2021-02-22T09:21:30Z
dc.date.available2021-02-22T09:21:30Z
dc.date.issued2015
dc.description.abstractWe describe a novel wound dressing (HR006) with two components: a lyophilized matrix of the galactomannan from locust bean gum (LBG) and an antioxidant hydration solution (AHsol ) containing curcumin and N-acetyl-L-cysteine (NAC). Physicostructural analyses of the LBG matrix revealed homogeneous interconnected pores with high absorbing capacity showing excellent properties for moist wound care (MWC). In an in vitro oxidative stress fibroblast injury model, the AHsol showed relevant protective effects reducing intracellular reactive oxygen species (ROS) production, rescuing cell viability, and regulating expression of inflammation-related genes (COX-2, TNFα, IL-1α, IL-1β). The new dressing showed good biocompatibility profile as demonstrated by cytotoxicity, hemocompatibility, and skin irritation tests. Moreover, in an in vivo skin wound model in pigs, this dressing enhanced the production of healthy and organized granulation tissue and re-epithelization. In summary, HR006 exhibits significant antioxidant activity, good biocompatibility, and excellent repair capabilities improving tissue remodeling and the healing of wounds.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 12, (2015)
dc.identifier.doi10.14670/HH-11-646
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/103662
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectGalactomanan-based matrixes
dc.subjectAntioxidant wound dressinges
dc.subjectSkin wound healinges
dc.subjectOxidative stresses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleDevelopment and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healinges
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nº12 (2015)