Publication: Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing
Authors
Castro, Begoña ; Palomares, Teodoro ; Azcoitia, Iker ; Bastida, Felix ; del Olmo, Maite ; Soldevilla, Javier J. ; Alonso-Varona, Ana
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-646
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info:eu-repo/semantics/article
Description
Abstract
We describe a novel wound dressing
(HR006) with two components: a lyophilized matrix of
the galactomannan from locust bean gum (LBG) and an
antioxidant hydration solution (AHsol
) containing
curcumin and N-acetyl-L-cysteine (NAC). Physicostructural analyses of the LBG matrix revealed
homogeneous interconnected pores with high absorbing
capacity showing excellent properties for moist wound
care (MWC). In an in vitro oxidative stress fibroblast
injury model, the AHsol showed relevant protective
effects reducing intracellular reactive oxygen species
(ROS) production, rescuing cell viability, and regulating
expression of inflammation-related genes (COX-2, TNFα, IL-1α, IL-1β). The new dressing showed good
biocompatibility profile as demonstrated by cytotoxicity,
hemocompatibility, and skin irritation tests. Moreover, in
an in vivo skin wound model in pigs, this dressing
enhanced the production of healthy and organized
granulation tissue and re-epithelization. In summary,
HR006 exhibits significant antioxidant activity, good
biocompatibility, and excellent repair capabilities
improving tissue remodeling and the healing of wounds.
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Citation
Histology and Histopathology, vol. 30, nº 12, (2015)
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