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The CCM3-GCKIII partnership

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dc.contributor.authorZalvide, Juan
dc.contributor.authorFidalgo, Miguel
dc.contributor.authorFraile, María
dc.contributor.authorGuerrero, Ana
dc.contributor.authorIglesias, Cristina
dc.contributor.authorFloridia, Ebel
dc.contributor.authorPombo, Celia M.
dc.date.accessioned2018-09-04T15:00:38Z
dc.date.available2018-09-04T15:00:38Z
dc.date.issued2013
dc.description.abstractSpecific mutations in the CCM3 gene predispose to the development of cerebral cavernous malformations, a special type of vascular lesions. This calls for an elucidation of the precise nature of the CCM3 protein and a deep understanding of its molecular regulation. In this review, we outline our current knowledge of the different CCM3 protein complexes. We focus on the GCKIII family of kinases as partners of CCM3 and discuss the functional consequences of this partnership, putting forward a putative model for the activation of these kinases.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 10 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/60848
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSte20 kinaseses
dc.subjectCavernous malformationses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleThe CCM3-GCKIII partnershipes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº10 (2013)