Publication:
The CCM3-GCKIII partnership

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Zalvide-28-1265-1272-2013.pdf(1.35 MB)
Date
2013
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Authors
Zalvide, Juan ; Fidalgo, Miguel ; Fraile, María ; Guerrero, Ana ; Iglesias, Cristina ; Floridia, Ebel ; Pombo, Celia M.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Specific mutations in the CCM3 gene predispose to the development of cerebral cavernous malformations, a special type of vascular lesions. This calls for an elucidation of the precise nature of the CCM3 protein and a deep understanding of its molecular regulation. In this review, we outline our current knowledge of the different CCM3 protein complexes. We focus on the GCKIII family of kinases as partners of CCM3 and discuss the functional consequences of this partnership, putting forward a putative model for the activation of these kinases.
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Ste20 kinases , Cavernous malformations
Citation
Histology and Histopathology, vol. 28, nº 10 (2013)
URI
http://hdl.handle.net/10201/60848
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Histology and histopathology Vol.28, nº10 (2013)
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