Publication:
Histopathological alterations in mice under sub-acute treatment with Hintonia latiflora methanolic stem bark extract

Simple item page
dc.contributor.authorFlores Jiménez, Nancy G.
dc.contributor.authorRojas Lemus, Marcela
dc.contributor.authorFortoul, Teresa I.
dc.contributor.authorZepeda Rodríguez, Armando
dc.contributor.authorLópez Camacho, Perla Y.
dc.contributor.authorAnacleto Santos, Jhony
dc.contributor.authorMalagón Gutiérrez, Filiberto
dc.contributor.authorBasurto Islas, Gustavo
dc.contributor.authorRivera Fernández, Norma
dc.date.accessioned2022-06-02T06:34:23Z
dc.date.available2022-06-02T06:34:23Z
dc.date.issued2018
dc.description.abstractThe indiscriminate use of herbal products is increasingly growing worldwide; nonetheless consumers are not warned about the potential health risks that these products may cause. Hintonia latiflora (Hl) is a tree native to the American continent belonging to the Rubiaceae family and its stem bark is empirically used mainly to treat diabetes and malaria; supplements containing Hl are sold in America and Europe without medical prescription, thus scientific information regarding its toxicity as a consequence of a regular consumption is needed. In the present study, the histopathological effect of 200 and 1000 mg/kg of Hl methanolic stem bark extract (HlMeOHe) was evaluated in the small bowel, liver, pancreas, kidneys and brain of CD-1 male mice after oral sub-acute treatment for 28 days. No histopathological alterations were observed in the brain of the treated animals; however, mice presented diarrhea from day 2 of treatment with both doses. No histological changes were observed in the tissues collected from the animals treated with 200 mg/kg, except for the liver that depicted periportal hepatitis. Animals treated with the higher dose showed in the liver sections hydropic degeneration, hepatitis and necrosis small bowel sections showed dilated mucosal vessels, kidney sections depicted tubular necrosis and in pancreas sections, hydropic degeneration of the pancreatic islets was observed. In conclusion, HlMeOHe damaged the liver with an oral dose of 200 mg/kg, and at 1000 mg/kg injured the kidneys and pancreas of the CD1 male mice.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol.33, nº12, (2018)
dc.identifier.doiDOI: 10.14670/HH-18-016
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/120805
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHintonia latifloraes
dc.subjectNatural productses
dc.subjectExtractses
dc.subjectHistopathologyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHistopathological alterations in mice under sub-acute treatment with Hintonia latiflora methanolic stem bark extractes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Flores-Jimenez-33-1299-1309-2018.pdf
Size:
25.57 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.33,nº12 (2018)