Publication: Histopathological alterations in mice under sub-acute treatment with Hintonia latiflora methanolic stem bark extract
Authors
Flores Jiménez, Nancy G. ; Rojas Lemus, Marcela ; Fortoul, Teresa I. ; Zepeda Rodríguez, Armando ; López Camacho, Perla Y. ; Anacleto Santos, Jhony ; Malagón Gutiérrez, Filiberto ; Basurto Islas, Gustavo ; Rivera Fernández, Norma
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-016
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info:eu-repo/semantics/article
Description
Abstract
The indiscriminate use of herbal products is
increasingly growing worldwide; nonetheless consumers
are not warned about the potential health risks that these
products may cause. Hintonia latiflora (Hl) is a tree native
to the American continent belonging to the Rubiaceae
family and its stem bark is empirically used mainly to
treat diabetes and malaria; supplements containing Hl are
sold in America and Europe without medical prescription,
thus scientific information regarding its toxicity as a
consequence of a regular consumption is needed. In the
present study, the histopathological effect of 200 and 1000
mg/kg of Hl methanolic stem bark extract (HlMeOHe)
was evaluated in the small bowel, liver, pancreas, kidneys
and brain of CD-1 male mice after oral sub-acute
treatment for 28 days. No histopathological alterations
were observed in the brain of the treated animals;
however, mice presented diarrhea from day 2 of treatment
with both doses. No histological changes were observed
in the tissues collected from the animals treated with 200
mg/kg, except for the liver that depicted periportal
hepatitis. Animals treated with the higher dose showed in
the liver sections hydropic degeneration, hepatitis and
necrosis small bowel sections showed dilated mucosal
vessels, kidney sections depicted tubular necrosis and in
pancreas sections, hydropic degeneration of the
pancreatic islets was observed. In conclusion, HlMeOHe
damaged the liver with an oral dose of 200 mg/kg, and at
1000 mg/kg injured the kidneys and pancreas of the CD1 male mice.
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Citation
Histology and Histopathology, Vol.33, nº12, (2018)
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