Publication: Serrated adenoma of the stomach: A clinicopathologic, immunohistochemical,
and molecular study of nine cases
Authors
Kwon, Mi Jung ; Min, Byung-Hoon ; Lee, Sun-Mi ; Park, Ha Young ; Kang, So Young ; Ha, Sang Yun ; Lee, Jun Haeng ; Kim, Jae J. ; Park, Cheol-Keun ; Kim, Kyoung-Mee
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Gastric serrated adenoma is a recently
recognized entity that has been rarely described and
poorly characterized. To examine whether gastric
serrated adenoma shares the same immunophenotypic
and molecular features of its colorectal traditional
serrated adenoma, the clinicopathologic features,
expression of mucin proteins (MUC2, MUC5AC, CD10,
MUC6) and mismatch repair protein (MLH1), and
mutations of BRAF and KRAS genes were studied.
The nine serrated adenomas were obtained from five
men and four women, with a mean age of 67 years.
Seven (78%) serrated adenomas were located in the
body of the stomach. The endoscopic findings were not
sufficiently characteristic to diagnose serrated adenoma
or serrated adenocarcinoma; however, most were
elevated lesions. The initial biopsy material was
available in all cases and the serrated features were
evident in 6 cases diagnosed as adenoma. Among the
nine cases, seven (78%) were associated with invasive
adenocarcinoma within the serrated adenoma. MUC5AC
was expressed in 6 serrated adenomas (67%). Expression
of MUC5AC was observed in all tumors located in the
lower third of the stomach. Focal MUC6 expression was
observed in the basal part of two serrated adenomas.
MLH1 expression was lost in two cases (22%). KRAS
mutations were observed in three cases (33%) while
BRAF mutations were not detected in any of the cases.
Gastric serrated adenoma does not completely share
the same immunophenotypic and molecular features of
its colorectal counterpart. Gastric serrated adenomas are
frequently associated with adenocarcinoma. When
serrated adenoma is encountered in a gastric biopsy
specimen, the possibility of associated adenocarcinoma
should be considered in the adjacent stomach.
Citation
Histology and histopathology, Vol. 28, n.º 4 (2013)
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.