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Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase

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dc.contributor.authorHonjo, Kie
dc.contributor.authorHiraki, Tsubasa
dc.contributor.authorHigashi, Michiyo
dc.contributor.authorNoguchi, Hirotsugu
dc.contributor.authorNomoto, Mitsuharu
dc.contributor.authorYoshimura, Takuya
dc.contributor.authorBatra, Surinder K.
dc.contributor.authorYonezawa, Suguru
dc.contributor.authorSemba, Ichiro
dc.contributor.authorNakamura, Norifumi
dc.contributor.authorTanimoto, Akihide
dc.contributor.authorYamada, Sohsuke
dc.date.accessioned2022-03-28T11:12:43Z
dc.date.available2022-03-28T11:12:43Z
dc.date.issued2018
dc.description.abstractIn mucoepidermoid carcinoma (MEC), the most common salivary gland carcinoma, there is a lack of novel prognostic markers, but post-operative early recurrence strongly affects the clinical course and a poor outcome. It is critical to predict which MEC patients are prone to develop recurrence/metastases. Mucins play pivotal roles in influencing cancer biology, thus affecting cell differentiation, adhesion, carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to elucidate the significance of expression profiles for mucins, particularly MUC4 and MUC6, and their correlations with various clinicopathological features and recurrence in salivary gland MECs. We performed immunohistochemical analyses on patients with surgically resected primary MEC using antibodies against mucin core proteins MUC4/8G7 and MUC6/CLH5 in 73 paraffin-embedded samples. Recurrence was noted in 15 of 73 (20.5%) patients. MUC4 or MUC6 expression was considered to be negative when <30% or 0% of the MEC cells showed positive staining, respectively. MUC4- and/or MUC6- negative expression respectively and variably showed a significant relationship to pathological tumor high-grade, the presence of lymphovascular invasion, lymph node metastasis and/or tumor-related death. In addition, MUC4 showed significantly negative co-expression with MUC6. Kaplan-Meier analyses revealed that not only single MUC4/6-negative expression but also the combination of both predicted significantly shorter disease-free and disease-specific survivals in MECs, especially within the first two years postoperatively. Therefore, each mucin plays a pivotal role in the pathogenesis of MEC progression. The detection of MUC4 and/or MUC6 might be a powerful parameter in the clinical management of MECs in the early postsurgical phase.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş2, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-913
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118387
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMucoepidermoid carcinoma (MEC)es
dc.subjectImmunohistochemistryes
dc.subjectMUC4es
dc.subjectMUC6es
dc.subjectDisease-free survival (DFS)es
dc.subjectDisease-specific survival (DSS)es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleImmunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş2 (2018)