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Regeneration of lingual musculature in rats using myoblasts over porcine bladder acellular matrix

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dc.contributor.authorCamacho Alonso, Fabio
dc.contributor.authorGarcía Carrillo, Nuria
dc.contributor.authorPeñarrocha Oltra, David
dc.contributor.authorPeñarrocha Diago, Miguel
dc.contributor.authorLacal Luján, José
dc.contributor.authorBuendía Marín, Antonio Julián
dc.contributor.authorNavarro Cámara, José Antonio
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-01-31T17:50:43Z
dc.date.available2024-01-31T17:50:43Z
dc.date.issued2021
dc.description.abstractObjectives: To use tissue engineering muscle repair (TEMR) for regenerating the lingual musculature of hemiglossectomized rats using neonatal myoblasts (NM) on porcine acellular urinary bladder matrix (AUBM). Material and Methods: The study used 80 male rats. A volumetric muscle loss (VML) injury was created on the left side of the tongue. The rats were randomized into four groups: Group 1 (AUBM + myoblasts); Group 2 (AUBM); Group 3 (myoblasts); and Group 4 (control). NM were obtained from neonatal rats. The animals were weighed on day 0 and just before euthanasia. Five rats in each group were euthanized at days 2, 14, 28, and 42; the tongues were prepared for morphometric analysis, postoperative left hemitongue weight, and immunohistochemical analysis (desmin, CD-31, and anti-neurofilament). Results: The weight gain from greatest to least was as follows: AUBM + myoblasts > myoblasts > AUBM > control. The tongue dorsum occupied by VML, and difference in mg between control side and intervened side from least to great was as follows: AUBM + myoblasts < myoblasts < AUBM < control. The order from highest to lowest antibody positivity was as follows: AUBM + myoblasts > myoblasts > AUBM > control. Conclusion: The use of porcine AUBM and NM for the regeneration of lingual musculature was found to be an effective TEMR treatment for repairing tongue VML injury.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationOral Diseases 2021 27(6):1580-1589
dc.identifier.doihttps://doi.org/10.1111/odi.13674
dc.identifier.issn1354-523X
dc.identifier.urihttp://hdl.handle.net/10201/138324
dc.languageenges
dc.publisherWileyes
dc.relationSin financiación externa a la Universidades
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHemiglossectomized tongueses
dc.subjectNeonatal myoblastses
dc.subjectPorcine acellular urinary bladder matrixes
dc.subjectTissue engineering muscle repaires
dc.subjectVolumetric muscle losses
dc.subject.otherCDU::5 - Ciencias puras y naturaleses
dc.titleRegeneration of lingual musculature in rats using myoblasts over porcine bladder acellular matrixes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc084ce85-206c-418d-8cec-7f85a0f34dc0
relation.isAuthorOfPublication41991b8b-3a95-46de-ab2a-b7968ee121e6
relation.isAuthorOfPublication.latestForDiscoveryc084ce85-206c-418d-8cec-7f85a0f34dc0
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