Publication:
Role of skeletal muscle in motor neuron development

Simple item page
dc.contributor.authorBaguma-Nibasheka, Mark
dc.contributor.authorFracassi, Anna
dc.contributor.authorCostain, Willard J.
dc.contributor.authorMoreno, Sandra
dc.contributor.authorKablar, Boris
dc.date.accessioned2021-07-27T11:04:08Z
dc.date.available2021-07-27T11:04:08Z
dc.date.issued2016
dc.description.abstractThe current paper is a continuation of our work most recently described in Kablar, 2011. Here, we show lists of up- and down-regulated genes obtained by a cDNA microarray analysis that compared developing mouse MyoD-/- limb musculature (MyoD-dependent, innervated by Lateral Motor Column motor neurons) and Myf5-/- back (epaxial) musculature (Myf5-dependent, innervated by Medial Motor Column motor neurons) to the control and to each other, at embryonic day 13.5 which coincides with the robust programmed cell death of motor neurons and the inability of myogenesis to undergo its normal progression in the absence of Myf5 and MyoD that at this embryonic day cannot substitute for each other. We wanted to see if/how the myogenic program couples with the neurotrophic one, and also to separate Lateral from Medial column trophic requirements, potentially relevant to Motor Neuron Diseases with the predilection for the Lateral column. Several follow-up steps revealed that Kif5c, Stxbp1 and Polb, differentially expressed in the MyoD-/- limb muscle, and Ppargc1a, Glrb and Hoxd10, differentially expressed in the Myf5-/- back muscle, are actually regulators of motor neuron numbers. We propose a series of follow-up experiments and various ways to consider our current dataes
dc.formatapplication/pdfes
dc.format.extent21es
dc.identifier.citationHistology and histopathology: Vol.31, nÂş7 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-742
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111367
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMyoDes
dc.subjectMyf5es
dc.subjectMyogenesises
dc.subjectNeurotrophinses
dc.subjectMotor neurones
dc.subjectMicroarrayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleRole of skeletal muscle in motor neuron developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Baguma-Nibasheka-31-699-719-2016.pdf
Size:
1.99 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.39 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.31, nÂş7 (2016)