Publication: Role of skeletal muscle in motor neuron development
Authors
Baguma-Nibasheka, Mark ; Fracassi, Anna ; Costain, Willard J. ; Moreno, Sandra ; Kablar, Boris
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-742
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info:eu-repo/semantics/article
Description
Abstract
The current paper is a continuation of our
work most recently described in Kablar, 2011. Here, we
show lists of up- and down-regulated genes obtained by
a cDNA microarray analysis that compared developing
mouse MyoD-/- limb musculature (MyoD-dependent,
innervated by Lateral Motor Column motor neurons) and
Myf5-/- back (epaxial) musculature (Myf5-dependent,
innervated by Medial Motor Column motor neurons) to
the control and to each other, at embryonic day 13.5
which coincides with the robust programmed cell death
of motor neurons and the inability of myogenesis to
undergo its normal progression in the absence of Myf5
and MyoD that at this embryonic day cannot substitute
for each other. We wanted to see if/how the myogenic
program couples with the neurotrophic one, and also to
separate Lateral from Medial column trophic
requirements, potentially relevant to Motor Neuron
Diseases with the predilection for the Lateral column.
Several follow-up steps revealed that Kif5c, Stxbp1 and
Polb, differentially expressed in the MyoD-/- limb
muscle, and Ppargc1a, Glrb and Hoxd10, differentially
expressed in the Myf5-/- back muscle, are actually
regulators of motor neuron numbers. We propose a series
of follow-up experiments and various ways to consider
our current data
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Citation
Histology and histopathology: Vol.31, nÂş7 (2016)
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