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Identification of changes in serum analytes and possible metabolic pathways associated with canine obesity-related metabolic dysfunction

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dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorBarić Rafaj, R.
dc.contributor.authorHorvatic, A.
dc.contributor.authorMuñoz Prieto, A.
dc.contributor.authorGuillermin, N.
dc.contributor.authorTumpa, A.
dc.contributor.authorCerón, J. J.
dc.contributor.authorMartínez Subiela, S.
dc.contributor.authorMrljak, V.
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-01-15T12:29:58Z
dc.date.available2025-01-15T12:29:58Z
dc.date.issued2019-02
dc.description© 2018 Elsevier Ltd. This document is the Published version of a Published Work that appeared in final form in The Veterinary Journal. To access the final edited and published work see https://doi.org/10.1016/j.tvjl.2018.12.006es
dc.description.abstractThe main objective of this study was to identify analytes that could change and that could help to clarify the metabolic and physiopathological changes related to canine obesity-related metabolic dysfunction (ORMD). For this, serum from 35 overweight/obese dogs, with and without ORMD, was submitted to a comprehensive panel of biochemistry analysis, a gel-free tandem mass tag isobaric label-based proteomic analysis, and, finally, selected proteins were used as a starting point for creating a protein interaction network. Dogs with ORMD showed significantly higher serum concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), Ca, total proteins, albumin, total cholesterol, triglycerides, glucose, and butyrylcholinesterase (BChE) activity in comparison with dogs without ORMD. Proteomic analysis revealed that 23 proteins related to lipid metabolism, the complement factor system, cellular adhesion and functionality, inflammation, and coagulation were altered in dogs with ORMD. Finally, the obtained protein interaction network highlighted that the central term of this network was the negative regulation of the immune response. These data suggest that canine ORMD is associated with changes in analytes that reflect altered lipid metabolism, and liver and immune function impairment and suggests the potential for a prothrombotic state and lung function alterations.es
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dc.format.extent9es
dc.identifier.citationThe Veterinary Journal , 2019, Vol. 244, pp. 51-59
dc.identifier.doihttps://doi.org/10.1016/j.tvjl.2018.12.006
dc.identifier.issnPrint: 1090-0233
dc.identifier.issnElectronic: 1532-2971
dc.identifier.urihttp://hdl.handle.net/10201/148502
dc.languageenges
dc.publisherElsevieres
dc.relationFinancial support was provided by a grant from the Robles Chillida foundation through its support programme for the promotion on research in Health Sciences, a grant of the programme for research groups of excellence of the Seneca Foundation, Murcia, Spain (grant 19894/GERM/15), by VetMedZg project of ERA Chair initiative (No. 621394), by European Structural and Investment Funds (Grant Agreement KK.01.1.16.0004), by the programme ‘Juan de la Cierva Incorporacion’ of ‘Ministerio de Economia y Competitividad’, Spain, through a postdoctoral grant (AT), Portuguese National funds through FCT under the project UID/AGR/00115/2013, by the FCT — Portuguese Science Foundation research contract IF/01778/2013 (EL), and the University of Murcia funded AMP through a predoctoral grant.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S109002331830772X?via%3Dihubes
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDoges
dc.subjectMetabolic syndromees
dc.subjectObesityes
dc.subjectProtein networkes
dc.subjectProteomicses
dc.titleIdentification of changes in serum analytes and possible metabolic pathways associated with canine obesity-related metabolic dysfunctiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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