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Three-dimensional epithelial cultures: a tool to model cancer development and progression

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dc.contributor.authorEritja, Núria
dc.contributor.authorDolcet, Xavier
dc.contributor.authorMatias-Guiu, Xavier
dc.date.accessioned2018-09-03T18:09:58Z
dc.date.available2018-09-03T18:09:58Z
dc.date.issued2013
dc.description.abstractLoss of cell polarity is a hallmark of cancer, and although this feature is commonly observed in advanced tumors; growing evidence indicates that loss of cell-cell adhesion and cell polarity may also be important in early stages of cancer. Despite recent important advances, much remains unclear about the molecular and biophysical mechanisms involved in phenotypic changes observed in epithelial architecture during carcinogenesis. Over the past decade the use of three dimensional cultures (3D) has emerged as a valuable tool to study the functions of cancer genes and pathways in an adequate polarized context. 3D cultures are an outstanding tool to understand the morphologic consequences of molecular alterations. In other words, 3D cultures allow a much better understanding of the pathological features of tumours, with the microscope. In this review we will focus on how 3D models have provided unique insights into how basic cell biological processes impact in higher-order tissue architecture and how these models have enhanced our understanding of carcinoma biology.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 10 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/60781
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCell polarityes
dc.subjectEpithelial tissueses
dc.subjectGlandular epitheliumes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThree-dimensional epithelial cultures: a tool to model cancer development and progressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº10 (2013)