Publication: Three-dimensional epithelial cultures: a tool
to model cancer development and progression
Authors
Eritja, Núria ; Dolcet, Xavier ; Matias-Guiu, Xavier
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Loss of cell polarity is a hallmark of cancer,
and although this feature is commonly observed in
advanced tumors; growing evidence indicates that loss
of cell-cell adhesion and cell polarity may also be
important in early stages of cancer. Despite recent
important advances, much remains unclear about the
molecular and biophysical mechanisms involved in
phenotypic changes observed in epithelial architecture
during carcinogenesis. Over the past decade the use of
three dimensional cultures (3D) has emerged as a
valuable tool to study the functions of cancer genes and
pathways in an adequate polarized context. 3D cultures
are an outstanding tool to understand the morphologic
consequences of molecular alterations. In other words,
3D cultures allow a much better understanding of the
pathological features of tumours, with the microscope.
In this review we will focus on how 3D models have
provided unique insights into how basic cell biological
processes impact in higher-order tissue architecture and
how these models have enhanced our understanding of
carcinoma biology.
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Citation
Histology and Histopathology, vol. 28, nº 10 (2013)
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