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Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

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dc.contributor.authorCastillo-Felipe, candela
dc.contributor.authorFranco-Martínez, Lorena
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorLopez Jornet, Pia
dc.contributor.authorLamy, Elsa
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-01-25T12:51:44Z
dc.date.available2024-01-25T12:51:44Z
dc.date.issued2021-05-01
dc.description©2021. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Biologyes
dc.description.abstractBurning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. The disease affects 0.7–15% of the general population, being most common in post-menopausal women. Although BMS is related to anxiety and/or depression and sleep disturbances, its etiology as well as its diagnosis remain unclear. Therefore, the present study aimed to contribute to the knowledge about this syndrome and to look for objective diagnostic tools. Therefore, whole saliva proteomes of patients suffering from BMS were compared to those of healthy persons. The results of this study manifest alterations in salivary proteins related to stress, immune system, and inflammation and, therefore, suggest implication of these pathways in BMS development. Moreover, biomarkers related to stress, immune system, and inflammation, such as salivary amyloid A, immunoglobulins, or leukocyte elastase inhibitors, among others, could contribute to BMC management, although further research is needed to confirm these suppositions.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationBiology 2021, 10, 392
dc.identifier.doi10.3390/biology10050392
dc.identifier.issnElectronic: 2079-7737
dc.identifier.urihttp://hdl.handle.net/10201/137747
dc.languageenges
dc.publisherMDPIes
dc.relationsupported by the Ministerio de Economía y Competitividad, Agencia Estatal de Investigación (AEI), Spain, and The European Social Fund (ESF). EL was supported by the FCT–Foundation for Science and Technology research contract CEECIND/04397/2017es
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/10/5/392es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBurning mouth syndromees
dc.subjectSalivaes
dc.subjectProteomicses
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleProteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndromees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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