Publication: Proteomics-Based Identification of Salivary Changes in Patients
with Burning Mouth Syndrome
Authors
Castillo-Felipe, candela ; Franco-Martínez, Lorena ; Tvarijonaviciute, Asta ; Lopez Jornet, Pia ; Lamy, Elsa
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Publisher
MDPI
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DOI
10.3390/biology10050392
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info:eu-repo/semantics/article
Description
©2021. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in
Biology
Abstract
Burning mouth syndrome (BMS) is a chronic oral condition characterized by an
intraoral burning sensation, taste alterations, and dry mouth sensations. The disease affects 0.7–15%
of the general population, being most common in post-menopausal women. Although BMS is related
to anxiety and/or depression and sleep disturbances, its etiology as well as its diagnosis remain
unclear. Therefore, the present study aimed to contribute to the knowledge about this syndrome
and to look for objective diagnostic tools. Therefore, whole saliva proteomes of patients suffering
from BMS were compared to those of healthy persons. The results of this study manifest alterations
in salivary proteins related to stress, immune system, and inflammation and, therefore, suggest
implication of these pathways in BMS development. Moreover, biomarkers related to stress, immune
system, and inflammation, such as salivary amyloid A, immunoglobulins, or leukocyte elastase
inhibitors, among others, could contribute to BMC management, although further research is needed
to confirm these suppositions.
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Citation
Biology 2021, 10, 392
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