Induction and stability of the anergic phenotype in T cells

Macián, Fernando; Valdor Alonso, Rut

Publication:
Induction and stability of the anergic phenotype in T cells

dc.contributor.author	Macián, Fernando
dc.contributor.author	Valdor Alonso, Rut
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2025-01-17T12:31:46Z
dc.date.available	2025-01-17T12:31:46Z
dc.date.issued	2013-11-15
dc.description	© 2013 Elsevier Ltd. This document is the Published Manuscript version of a Published Work that appeared in final form in Seminars in Immunology. To access the final edited and published work see https://doi.org/10.1016/j.smim.2013.10.010
dc.description.abstract	One of the mechanisms that are in place to control the activation of mature T cells that bear self-reactive antigen receptors is anergy, a long-term state of hyporesponsiveness that is established in T cells in response to suboptimal stimulation. T cells receive signals that result not only from antigen recognition and costimulation but also from other sources, including cytokine receptors, inhibitory receptors or metabolic sensors. Integration of those signals will determine T cell fate. Under conditions that induce anergy, T cells activate a program of gene expression that leads to the production of proteins that block T cell receptor signaling and inhibit cytokine gene expression. In this review we will examine those signals that determine functional outcome following antigen encounter, review current knowledge of the factors that ensure signaling inhibition and epigenetic gene silencing in anergic cells and explore the mechanisms that lead to the reversal of anergy and the reacquisition of effector functions
dc.format	application/pdf	es
dc.identifier.citation	Seminars in Immunology, 2013, Vol. 25, Issue 4, pp. 313-320
dc.identifier.doi	https://doi.org/10.1016/j.smim.2013.10.010
dc.identifier.issn	Print: 1044-5323
dc.identifier.issn	Electronic: 1096-3618
dc.identifier.uri	http://hdl.handle.net/10201/148713
dc.language	eng	es
dc.relation	This work was supported by NIH grant AI059738	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1044532313000912?via%3Dihub
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Anergy induction
dc.subject	Anergy reversal
dc.subject	NFAT
dc.subject	Epigenetics
dc.title	Induction and stability of the anergic phenotype in T cells	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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