Publication: Induction and stability of the anergic phenotype in T cells
Authors
Macián, Fernando ; Valdor Alonso, Rut
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Publisher
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DOI
https://doi.org/10.1016/j.smim.2013.10.010
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info:eu-repo/semantics/article
Description
© 2013 Elsevier Ltd. This document is the Published Manuscript version of a Published Work that appeared in final form in Seminars in Immunology. To access the final edited and published work see https://doi.org/10.1016/j.smim.2013.10.010
Abstract
One of the mechanisms that are in place to control the activation of mature T cells that bear self-reactive
antigen receptors is anergy, a long-term state of hyporesponsiveness that is established in T cells in
response to suboptimal stimulation. T cells receive signals that result not only from antigen recognition and costimulation but also from other sources, including cytokine receptors, inhibitory receptors or
metabolic sensors. Integration of those signals will determine T cell fate. Under conditions that induce
anergy, T cells activate a program of gene expression that leads to the production of proteins that block
T cell receptor signaling and inhibit cytokine gene expression. In this review we will examine those signals that determine functional outcome following antigen encounter, review current knowledge of the
factors that ensure signaling inhibition and epigenetic gene silencing in anergic cells and explore the
mechanisms that lead to the reversal of anergy and the reacquisition of effector functions
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Citation
Seminars in Immunology, 2013, Vol. 25, Issue 4, pp. 313-320
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