Publication:
Increased expression of annexin A7 in temporal lobe tissue of patients with refractory epilepsy

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dc.contributor.authorZhou, Sheng-nian
dc.contributor.authorLi, Cheng-shan
dc.contributor.authorLiu, L.
dc.contributor.authorLi, Y.
dc.contributor.authorWang, X.
dc.contributor.authorShen, Lan
dc.date.accessioned2016-04-13T10:39:34Z
dc.date.available2016-04-13T10:39:34Z
dc.date.issued2011
dc.description.abstractAnnexin A7 is a member of the family of annexins, which are thought to function in the regulation of calcium homeostasis and the fusion of vesicles. Refractory epilepsy may be related to the imbalance of calcium homeostasis. Our aims are to investigate the expression of Annexin A7 in epileptic brains in comparison with human controls and to explore Annexin A7’s possible role in refractory epilepsy. We examined the expression of Annexin A7 via immunohistochemistry, double-label immuno-fluorescence and western blot. The expression of Annexin A7 was shown to be significantly increased in patients with refractory epilepsy. Double-label immunofluorescence and confocal microscopy disclosed Annexin A7 immunoreactivity in the neurons, which were recognized by the antibody of neuron specific enolase (NSE). The result showed that Annexin A7 may be involved in the pathophysiology of refractory epilepsy and may play a role in developing and maintaining the epilepsy.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48562
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and Histopathology, vol. 26, nº 5 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAnnexins A7es
dc.subjectRefractory epilepsyes
dc.subjectCalcium homeostasises
dc.subject.other61 - Medicinaes
dc.titleIncreased expression of annexin A7 in temporal lobe tissue of patients with refractory epilepsyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº5 (2011)