Publication: Increased expression of annexin A7 in temporal
lobe tissue of patients with refractory epilepsy
Authors
Zhou, Sheng-nian ; Li, Cheng-shan ; Liu, L. ; Li, Y. ; Wang, X. ; Shen, Lan
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Annexin A7 is a member of the family of
annexins, which are thought to function in the regulation
of calcium homeostasis and the fusion of vesicles.
Refractory epilepsy may be related to the imbalance of
calcium homeostasis. Our aims are to investigate the
expression of Annexin A7 in epileptic brains in
comparison with human controls and to explore Annexin
A7’s possible role in refractory epilepsy. We examined
the expression of Annexin A7 via immunohistochemistry,
double-label immuno-fluorescence and
western blot. The expression of Annexin A7 was shown
to be significantly increased in patients with refractory
epilepsy. Double-label immunofluorescence and
confocal microscopy disclosed Annexin A7
immunoreactivity in the neurons, which were recognized
by the antibody of neuron specific enolase (NSE). The
result showed that Annexin A7 may be involved in the
pathophysiology of refractory epilepsy and may play a
role in developing and maintaining the epilepsy.
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