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Fli-1 expression in malignant melanoma

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dc.contributor.authorTorlakovic, Emina E.es
dc.contributor.authorSlipicevic, Anaes
dc.contributor.authorFlørenes, Vivi Ann
dc.contributor.authorChibbar, Richa
dc.contributor.authorDeCoteau, John F.
dc.contributor.authorBilalovic, Nurija
dc.date.accessioned2013-01-22T10:04:34Z
dc.date.available2013-01-22T10:04:34Z
dc.date.issued2008
dc.description.abstractFriend leukemia integration site 1 (Fli-1) has been reported as the first nuclear marker of endothelial differentiation; it is expressed in leukocytes and recently demonstrated in melanomas. Formalin-fixed, paraffinembedded tissue sections from 97 melanomas including 69 cases of primary and 28 metastatic melanomas were evaluated by immunohistochemistry. Five melanoma cell lines were evaluated by Western blot and immunocytochemistry. Fli-1 expression was observed in all cell lines. Fli-1 expression was higher in metastatic than in primary tumors (r=0.208, p=0.041, Spearman correlation), it positively correlated with Ki-67 expression (r=0.233, p=0.022, Spearman correlation), and the presence of an ulcer in the primary tumor (r=0.267, p=0.030, Spearman correlation). Therefore, the expression of Fli-1 in malignant melanoma appears to be associated with biologically more aggressive tumors.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29851
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMelanomaes
dc.subjectFli-1es
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleFli-1 expression in malignant melanomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23,nº11 (2008)