Publication: Fli-1 expression in malignant melanoma
Authors
Torlakovic, Emina E. ; Slipicevic, Ana ; Flørenes, Vivi Ann ; Chibbar, Richa ; DeCoteau, John F. ; Bilalovic, Nurija
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Friend leukemia integration site 1 (Fli-1) has
been reported as the first nuclear marker of endothelial
differentiation; it is expressed in leukocytes and recently
demonstrated in melanomas. Formalin-fixed, paraffinembedded
tissue sections from 97 melanomas including
69 cases of primary and 28 metastatic melanomas were
evaluated by immunohistochemistry. Five melanoma cell
lines were evaluated by Western blot and
immunocytochemistry. Fli-1 expression was observed in
all cell lines. Fli-1 expression was higher in metastatic
than in primary tumors (r=0.208, p=0.041, Spearman
correlation), it positively correlated with Ki-67
expression (r=0.233, p=0.022, Spearman correlation),
and the presence of an ulcer in the primary tumor
(r=0.267, p=0.030, Spearman correlation). Therefore, the
expression of Fli-1 in malignant melanoma appears to be
associated with biologically more aggressive tumors.
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